AC Milan (ITA) – FC Zürich (SUI)
FC Timisoara (ROU) – Partizan Belgrade (SER)
Hertha Berlin (ALL) – St Patrick's (IRL)
Banik Ostrava (RTC) – Spartak Moscou (RUS)
Metalist Kharkiv (UKR) – Besiktas (TUR)
Portsmouth (ANG) – Vitoria Guimaraes (POR)
Kayserispor (TUR) – Paris Saint-Germain
FC Séville (ESP) – FC Salzbourg (AUT)
Wolfsburg (ALL) – Rapid Bucarest (ROU)
Sampdoria Gènes (ITA) – FBK Kaunas (LIT)
Maritimo Funchal (POR) – Valence CF (ESP)
Dinamo Zagreb (CRO) – Sparta Prague (RTC)
Manchester City (ANG) – Omonia (CHY)
YB Berne (SUI) – Club Bruges (BEL)
AS Nancy-Lorraine – Motherwell (ECO)
Everton (ANG) – Standard de Liège (BEL)
Naples (ITA) – Benfica (POR)
Bellinzone (SUI) – Galatasaray (TUR)
NEC Nimègue (PBS) – Dinamo Bucarest (ROU)
Racing Santander (ESP) – Honka Espoo (FIN)
Apoel FC (CHY) – Schalke 04 (ALL)
Litex Lovech (BUL) – Aston Villa (ANG)
Austria Vienne (AUT) – Lech Poznan (POL)
Vitoria Setubal (POR) – Heerenveen (PBS)
Brann Bergen (NOR) – La Corogne (ESP)
Slavia Prague (RTC) – Vaslui (ROU)
Slaven Koprivnica (CRO) – CSKA Moscou (RUS)
Brondby (DAN) – Rosenborg (NOR)
Cherno More Varna (BUL) – VfB Stuttgart (ALL)
Stade Rennais FC – Twente (PBS)
Ajax Amsterdam (PBS) – FK Borac (SER)
Tottenham (ANG) – Wisla Cracovie (POL)
FC Copenhague (DAN) – FC Moscou (RUS)
MSK Zilina (SVQ) – Levski Sofia (BUL)
Borussia Dortmund (ALL) – Udinese (ITA)
SC Braga (POR) – Artmedia Petrzalka (SVQ)
Feyenoord (PBS) – Kalmar (SUE)
Hambourg (ALL) – AFC Unirea Urziceni (ROU)
Hapoel Tel Aviv (ISR) – AS Saint-Etienne
Nordsjaelland (NOR) – Olympiakos (GRE)
Matches aller le jeudi 18 septembre 2008 - Matches retour le jeudi 2 octobre